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Interaction Between Type 2 Diabetes Prevention Strategies and Genetic Determinants of Coronary Artery Disease on Cardiometabolic Risk Factors

Published 17 January 2020

Coronary artery disease (CAD) is more frequent among individuals with dysglycemia. Preventive interventions for diabetes can improve cardiometabolic risk factors (CRFs), but it is unclear whether the benefits on CRFs are similar for individuals at different genetic risk for CAD. We built a 201-variant polygenic risk score (PRS) for CAD and tested for interaction with diabetes prevention strategies on one-year changes in CRFs in 2,658 Diabetes Prevention Program participants. We also examined whether separate lifestyle behaviors interact with PRS on changes in CRFs in each intervention group.

New publication in American Diabetes Association

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Page manager: anna_e [dot] larsson [at] med [dot] lu [dot] se | 25 Jan 2021